Nilanjan Samanta, Rumiya Biswas, Susmita Pal, Anindya Bagchi*, Prosenjit Mukherjee, Anusree Raha, Monit Pal, Abhik Si
Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, Westbengal, India.
*Corresponding Author
Anindya Bagchi
Assistant Professor
Netaji Subhas Chandra Bose Institute of Pharmacy, West Bengal, India
Abstract
Objective: The objective of the work is to develop a simple precise, rapid accurate, sensitive and comparative electrochemical titrimetric method for quantitative determination of aspirin in pharmaceutical dosage form. Material and methods: The titration was carried out using standardized 0.1 M sodium hydroxide against formulated aspirin sample and all the results were statistically validated. Here Potentiometric and Conductometric titration method were used. Results and Discussion: The proposed potentiometric method was found to be precise with % RSD <1 (n = 5) as the method showed strict linearity (r2 > 0.99) in between 100-200 mg of drug substance weight. The percentage recovery of aspirin in the optimized method was found to be lies in between 97 % to 101 %. The proposed conductometric method was found to be precise with % RSD >1 (n = 6). The method showed strict linearity (r2 > 0.99) between 100-200 mg of drug substance weight. The percentage recovery of aspirin in the optimized method was almost 100% to the corresponding 100 and 300 mg of the drug. Conclusion: Potentiometric method was seems to have more effective one rather than the conductometric method one as aspirin can be assayed electrochemically with in concentration range with this validated method that was optimized without the effect of excipients.
Keywords: Validation, Titration, Potentiometric method, Conductometric method, precision, Percentage recovery
