Research Articles

2019  |  Vol: 5(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2019.5.1.22

In vivo assessment of antifertility potential of Pteridophytic plants: Actiniopteris radiata (SW.) L. and Selaginella bryopteris (L.) Baker in swiss albino mice

Jyothi Chandrakant^{1, 2}, Arjun N. Shetty^{1, 2}, Sundar Mety², Md. Liyakat Ali³, Pratima Mathad^2*

¹Department of P. G. Studies in Botany, Sharnbasva University, Kalaburagi, Karnataka, India

²Department of P. G. Studies and Research in Botany, Gulbarga University, Kalaburagi, Karnataka, India

³Luqman College of Pharmacy, Kalaburagi, Karnataka, India

*Address for Corresponding Author

Dr. Pratima Mathad

Department of P. G. Studies and Research in Botany, Gulbarga University, Kalaburagi, Karnataka, India

Abstract

Objective: Population explosion is a foremost problem and its control in colonized countries may have an effect on the economic growth, in this regard family planning has been promoted through several methods of contraception, however current methods of contraception result in undesirable side effect. Thus there is a need to replace these agents with potent drugs with least or zero side effects. Hence, the present study was undertaken to evaluate the antifertility properties of Actiniopteris radiata and Selaginella bryopteris on female albino mice. Material and methods: Experimental mice were orally administered with methanol extract of Actiniopteris radiata (175 and 300 mg/kg body weight) and Selaginella bryopteris (250 and 500 mg/kg body weight) for 30 days. Effect of the treatment on female reproductive organ was investigated and level of oestrogen was determined by ECLIA oestrogen standard kit. Quantitative estimations of protein, cholesterol and alkaline phosphatase of blood serum were carried out using Biosystems Diagnostics standard kit. Results and conclusion: The treatment showed decrease in weight of the ovary and decrease in oestrogen level and on the other hand histological changes were also observed. The overall results of the present study revealed that the low dose of (175 mg/kg body weight) methanolic extract of A. radiata induced infertility whereas in high dose (300 mg/kg body weight) it is not observed. While S. bryopteris had notshown much significant variation in female albino mice when compared to control.

Keywords: Antifertility, Actiniopteris radiata, Selaginella bryopteris, oestrogen, Pteridophytes