Suresh Kumar Dev1*, Ajay Shukla1, P. K. Choudhury1, G.K Singh2
1Department of Pharmaceutical Science, Mohanlal Sukhadia University Udaipur Rajasthan, India
2Department of Pharmacognosy, Lachoo Memorial College of Science and Technology Pharmacy Jodhpur, Rajasthan India
*Correspondence Address
Suresh Kumar Dev
Department of Pharmaceutical Science,
Mohanlal Sukhadia University Udaipur Rajasthan, India
Email: sureshdev04@gmail.com
Abstract
Objectives: To study the analgesic and anti-nociceptive activity of hydro-ethanolic stem extract of Capparis decidua (Forssk.) Edgew. Materials and methods: Wistar rats and Swiss albino mice were selected for study of analgesic and anti-nociceptive activity of Capparis decidua hydro-ethanolic extract (CDHE) at doses 50, 100 and 200 mg/kg p.o. a variety of models viz. acetic acid induced writhing model (female mice), Eddy's hot plate (mice) and tail flick model for analgesic study, and formalin-induced paw licking model (mice) were usedforanti-nociceptivestudy. Results: In acetic acid induced writhing model and in the hot plate model method used with indomethacin standard drug, the maximum effect was observed at 60 min at a dose of 200 mg/kg p.o., which was higher than the standard drug morphine sulfate (1.5 mg/kg i.p.) while in the tail flick model, effect was comparable with morphine sulfate. In formalin-induced paw licking model, administration of CDHE completely abolished the early phase at 100 and 200 mg/kg p.o. and in the late phase, the result of CDHE (200 mg/kg p.o.) was superior than indomethacin (10 mg/kg p.o.). CDHE was effective in both non-narcotic and narcotic models of nociception, signifying its possible action via peripheral and central mechanism. It also abolished the early phase in formalin-induced paw licking model, signifying complete inactivation of C-fiber at higher dose. Conclusion: The activity can be recognized to the phyto-constituents viz tannins, diterpenes, triterpenes and steroids present in the CDHE extract. In conclusion, CDHE can be developed as a potent analgesic and anti-nociceptive agent in future.
Keywords: Analgesic, acetic acid, Capparis decidua , Eddy′s hot plate, hydro-ethanol extract, tail flick
