Objective: The chemistry of β-lactams has established a prestigious role in organic and medicinal chemistry. The combination of these derivatives with other medicinally important class like glycolylurea might give some more applicable compounds. The objective of the present work was the synthesis and characterization of glycolylurea derivatives of some β-lactams. The synthesis involving formation of glycolylurea derivatives followed by the condensation was performed as per previously used methods. Materials and Methods: The synthesized compounds were characterized by various physico-chemical and analytical methods including FTIR and NMR spectroscopy. All the compounds were also investigated for their antimicrobial activity on gram negative and gram positive microbial cultures. Results and conclusions: It was found that from the investigated compounds one compound G5 mono-chloro derivative with one methyl group at ortho position was found active against gram nagetive microbes P. aeruginosa and G7 di-chloro derivative with one methyl group at ortho position was found active against gram positive microbes B. subtilis. Four out of eight compounds are moderately active against E. coli. Except G8 all the synthesized compounds are less or very less active against selected fungal stains.

Keywords: Glycolylurea, β-lactams, antimicrobial activity