Research Articles

2019  |  Vol: 5(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2019.5.1.21

Reducing power and superoxide radical scavenging activity of a triterpene derivative isolated from root bark of Zizyphus nummularia Aubrev

Sarbani Dey Ray^{1, 2}

¹Department of Pharmaceutical Sciences, Assam University, Silchar, Assam, India,

²Dr. B. C. Roy College of Pharmacy & A.H.S, Durgapur, West Bengal, India

*Address for Corresponding author

Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar, Assam, India

Abstract

Objective: The aim of the study is to investigate the reducing power and superoxide radical scavenging activity of the ethanolic extract (EE) and an identified lead compound (LC) which is a triterpene derivative isolated from root bark of Zizyphus nummularia. Material and methods: The in vitro evaluation of antioxidant activities of ethanolic extract (EE) and an identified lead compound (LC) was done by measuring reducing power, superoxide radical. Results and conclusion: The result showed that the reducing power and superoxide radical scavenging activity of EE, LC followed a dose dependent pattern. The IC₅₀ values for LC are comparatively lower than EE. So, the study showed that EE and LC of Z. nummularia have potent reducing power and superoxide radical inhibitory activity.

Keywords: Zizyphus nummularia, reducing power, superoxide radical, Octadecahydro-picene-2,3-14-15-tetranone