Sreya Kosanam
Department of clinical Pharmacy,
ASN Pharmacy College, Tenali, Guntur dist., Andhra Pradesh. India
*Corresponding author
Sreya Kosanam, Pharm D
Department of clinical Pharmacy,
ASN Pharmacy College,
Tenali, Guntur dist., Andhra Pradesh, India.
Abstract
Drug interactions are an important segment of drug related problems. Evaluation of Drug interactions is necessary along with patient management, especially in children and elderly patients who often receive multiple medications. Severity of drug-drug interactions is one of the problems which are poorly understood within the clinical medicine. It is increasingly necessary to become acquainted with the workings of protein bound metabolism and associated drug interaction which leads to increased free concentrations of drug in the body. In this manuscript drug interactions with emphasis on their relevance and mechanism are reviewed. Additionally, as an example of protein displacement drug-drug interaction between valporate and aspirin is discussed.
Keywords: Drug interactions, mechanisms, protein bound, valporate, aspirin
