Dilip Kumar Tiwari*, Kajal Sharma, Shivani Goyal, Kaushelendra Mishra, Abhishek Chaturvedi
Lakshmi Narain College of Pharmacy, Bhopal 462022, Madhya Pradesh, India
*Address for Corresponding Author
Dilip Kumar Tiwari
Lakshmi Narain College of Pharmacy, Bhopal
Raisen Road Bhopal-462022, Madhya Pradesh, India
Abstract
Background: Diabetes mellitus (DM) is one of the leading metabolic disorders worldwide. Diabetes mellitus is due to a lack of function of β pancreatic cells or insensitivity of target tissue to insulin. This disorder not only affects the metabolic system but also causes various associated problems like neuropathy, nephropathy, retinopathy, and heart-related disease. Treatment of Diabetes mellitus (DM) with allopathic drugs for a long duration has been not safer and may cause several adverse effects along with hypoglycemia. World health organization (WHO) recommended drug researchers emphasize herbal-based research which is safer and more effective for longer regimens in dosing. Objective: This work was aimed to attempt to explore roots extract of Aegle marmolus for antidaibetic potential by in vitro methods. Material and methods: In this research work Aegle marmolus roots extract were tested for anti-diabetic potential by in vitro method α–amylase inhibitory assay and Glucose uptake in yeast cells. Results and conclusion: Results were shown α-amylase inhibitory activities IC50 112 μg/ml. EEAMR exhibited highest percentage of glucose uptake i.e. 54.84±0.752, which was almost near to the standard i.e. 61.74±0.527. In conclusion antidiabetic effect of Aegle marmolus is attributed to the mixture of phytochemicals in the extracts. In present study extract showing excellent antidiabetic potential by in-vitro method. Possible activities due to presence of bioflavonoid & flavonoid constituents present in extract which mimic the insulin activity & glucose uptake by adipose tissue.
Keywords: diabetes mellitus, hypoglycemia, neuropathy, retinopathy, α-amylase, Aegle marmolus
