Manjunatha P. Mudagal*, Swathi K.
Department of Pharmacology,
Acharya and B.M. Reddy College of Pharmacy, Soldevanhalli, Acharya Dr. Sarvepalli Radhakrishna Road, Bangalore-560090, Karnataka, India
*Address Corresponding Author
Manjunatha P. Mudagal
Department of Pharmacology,
Acharya and B.M. Reddy College of Pharmacy,
Soldevanhalli, Acharya Dr. Sarvepalli Radhakrishna Road, Bangalore-560090, Karnataka, India
Abstract
Objective: Myocardial infarction (MI) increasingly contributing towards mortality statistics of CVD. The present study was aimed to investigate the cardioprotective effect of quercetin and catechin in isoproterenol induced myocardial infarcted rats. Material and methods: The cardioprotective effect was assessed by determining the effects of quercetin (30 and 60 mg/kg, p.o.,) and catechin (20 and 40 mg/kg, p.o.,) in isoproterenol induced myocardial infarction on the activities of cardiac markers, antioxidant enzymes and histopathological examination. Results: Administration of isoproterenol (150 mg/kg, s.c.) in rats at 24 h interval for 2 days showed significant (p<0.001) increase in cardiac markers (LDH, SGOT and SGPT), increase in MDA levels; significant decrease in antioxidant enzymes (SOD, GPX and CAT). Pretreatment with quercetin (30 and 60 mg/kg, p.o.,) and catechin (20 and 40 mg/kg, p.o.,) to isoproterenol treated rats for 42 days showed significant (p<0.001) protective effect and quercetin and catechin alone treated groups showed less significant effect. Conclusion: The study revealed that cardioprotective effect of quercetin and catechin in isoproterenol induced MI may be due to attenuation of antioxidant enzymes and inhibition of lipid peroxidation of membrane and decrease in cardiac marker levels, which was further confirmed by histopathological studies.
Keywords: Cardiovascular diseases, myocardial infarction, Isoproterenol, Quercetin, Catechin
