Vaishali Khatri1, Ketan Christi2
1Department of Physiology, SSR Medical College, Belle Rive, University of Mauritius, Mauritius.
2School of Biological and Chemical Sciences, University of the South Pacific, Suva, Fiji.
Address for Corresponding Author
Dr. Vaishali Khatri
Associate Professor in Physiology
SSR Medical College, Belle Rive, University of Mauritius.
Abstract
The benefits of aspirin have been studied extensively and its place in therapy has been established through many landmark clinical trials. Despite the proven efficacy in clinical studies, there is a growing concern regarding patients who continue to experience vascular thrombotic events despite receiving aspirin therapy. The aim of this review is to give an overview of the various clinical studies, discussing possible mechanisms, diagnostic testing and the prevalence of aspirin resistance. In recent years aspirin resistance has been in focus and the mechanisms to determine aspirin resistance are being studied. Several laboratory studies have reported variations in response to aspirin treatment and also the platelet function has been demonstrated to be normal in a considerable proportion of patients taking aspirin daily. However according to the available data and ongoing research, it has been shown that about 20% of the patients are resistant to the antiplatelet effects of aspirin, or the doses they are taking are too low to affect platelet aggregation.
Keywords: Aspirin, resistance, mechanism, clinical studies
