Geetha Rani Valaparla*, Gutta Vishnu Sai, Devireddysudheer Kumar
Department of Pharmacology, A.M. Reddy memorial College of Pharmacy, Petlurivaripalem, Narasaraopet, 522601 Guntur, Andhra Pradesh, India
*Address for Corresponding Authors
Geetha Rani Valaparla
Associate Professor
Department of Pharmacology,
A.M. Reddy memorial College of Pharmacy, Petlurivaripalem, Narasaraopet, 522601 Guntur, Andhra Pradesh
Abstract
Objective: Obesity is one of the world’s leading problems, which is major cause of Cardiovascular Diseases. During COVID - 19 pandemic many young children and all age group people are getting challenged by obesity due stagnant life style. To treat such life threatening disorder natural remedies acquire prior position, Plant produce a good deal of secondary metabolites which have a benefited mankind in various ways, including treatment of diseases The present research work was focused on developing a natural remedy using Tamarindus indica, an ancient plant with number of proven activities in Traditional medicine. Materials and Methods: In the literature survey, it was found that flavonoids, sterols, tannins and alkaloids shown promising effects to tackle obesity by various mechanisms, Tamarindus indica has shown the presence of saponins, flavonoids, glycosides, amino acids, alkaloids. With the above evidence, this plant has been selected for screening of its antiobesity activity against high fat diet induced obesity in mice. Studies were conducted using aqueous extract of Tamarindus indica leaves (AETI) on high fat diet (butter) induced model of hyperlipidemia in mice. Results and Discussion: During 21 days time period AETI low and high doses were induced to respective animal groups along with butter where Atorvastatin has been taken as standard drug. Butter enhanced the Cholesterol and triglyceride, LDL levels. At the end of 21 days blood samples were collected from the animal through retroperitoneal route. Biochemical parameters of AETI have been revealed its antiobesity activity.
Keywords: obesity, AETI, high fat diet, antiobesity, Atorvastatin
