Zeba Afrin1, Aisha Siddiqui2*, M. A. Jafri3, Divya Vohora4, M. Asif2
1Research Associate, Central Council for Research in Unani Medicine Headquarters, Janakpuri, New Delhi, India
2Assistant Professor, Department of Ilmul Advia, School of Unani Medical Education & Research, JamiaHamdard, New Delhi, India
3Professor, Department of Ilmul Advia, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India
4Professor and Head, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi
*Address for Correspondence:
Dr. Aisha Siddiqui
Department of Ilmul Advia, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India
Abstract
Objective: To compare the anticonvulsant activity of Majoon Najah, its hydroalcoholc extract and granular form through Increased Current Electroshock Seizure (ICES) test in swiss albino mice. Methods: Majoon Najah, its hydroalcoholic extract and granular form were tested for anticonvulsant activity using ICES animal model. To evaluate the effect of test drugs on motor co-ordination, muscle co-ordination test by rotarod was carried out. Results: In ICES test Seizure Threshold Current (STC), duration of hindlimb extension (HLE) and percent protection were observed. It was found that MN (p<0.01), HEMN and GMN (p<0.001) significantly increased the seizure threshold current when compared with control. Although HEMN increased the STC more significantly than MN and GMN but intra-comparison between MN, HEMN and GMN showed no statistical significant variation in the activity. Conclusion: It can be concluded from the experiment performed that Majoon Najah possess significant anticonvulsant activity.
Keywords: Majoon Najah, anticonvulsant, ICES
