Prathap Balasubramaniyan1*, Jacob Varghese Powathikunnil1, Sengottuvelu Singaravel2
1Department of Pharmacology, Karpaga Vinayaga Institute of Medical Sciences and Research Institute, Maduranthagam, Tamilnadu, India
2Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamilnadu, India
*Address for Correspondence
Dr. B. Prathap
Associate Professor
Karpaga Vinayaga Institute of Medical Sciences and Research Institute,
Maduranthagam, Kanchipuram District, Tamilnadu India
Abstract
Objective: The purpose of this study was to investigate the cough suppressant and expectorant activities of ethanolic extract of Pergularia daemia (100 and 200mg/kg) in mice. Materials and Methods: The cough suppressant activity of Pergularia daemia was evaluated against sulfur dioxide induced cough in mice. Codeine sulfate (30mg/kg) was used as reference control. Number of cough and percentage inhibition was measured after test drug administration. The expectorant activity was evaluated by the secretion of phenol red in mice tracheas which was measured by UV spectrophotometer and ammonium chloride was used as reference control. Results: In cough suppressant activity, both the doses of Pergularia daemiasignificantly (P<0.001) decrease the cough and the percentage inhibition of cough at 100 and 200mg/kg of Pergularia daemia was 50.81% and 64.54% respectively. In expectorant activity, both the doses of Pergularia daemia significantly (P<0.001) enhance the phenol red secretion and the percentage increase at 100 and 200mg/kg of Pergularia daemia was 53.13% and 65.63% respectively. Conclusion: From the result, it was concluded that, ethanolic extract of Pergularia daemia exhibited cough suppressant and expectorant activity against experimental animal models.
Keywords: Pergularia daemia, expectorant, cough suppressant, phenol red, sulfur dioxide
