Ankit Jain1, Santram Lodhi2*
1Vedica College of B. Pharmacy, Gandhinagar, Bhopal (M.P.) 462033 India
2Sri Sathya Sai Institute of Pharmaceutical Sciences, Gandhinagar, Bhopal (M.P.) 462033 India
*Address for Corresponding Author
Dr. Santram Lodhi
Sri Sathya Sai Institute of Pharmaceutical Sciences, Gandhinagar, Bhopal (M.P.) 462033 India
Abstract
Objective: Aim of present study was to study pharmacological screening of Ipomoea reniformis seeds extract for antiulcer effect on Pyloric ligation and ethanol-induced ulcer model. Material and methods: The antiulcer effect of standard drug ranitidine and plant extracts (Petroleum ether, Ethanol extract and Aqueous extract) were studied on the ulcer Index and extent of mucosal damage in the stomach. In present study, Ranitidine drug was used as reference for comparison of antiulcer effect. Results and conclusion: The present study showed that Ipomoea reniformis seeds extracts possess anti-ulcer activity in both animal models. The intensity of heamorrhage and lesions was significantly reduced with pretreatment and helpful for the protective effect of all extracts. The submucosal edema of animal treated with ethanolic plant extract of 500 mg/Kg dose showed reduced mucosal edema with wounds infiltration and the muscularis propria appears normal. Ipomoea reniformis seeds extract showed a significant decrease in the ulcer development in both the animal models pyloric ligation and ethanol-induced ulcer model. In pylorus ligation, both the doses showed significant anti-ulcer activity by reduction in ulcer index, gastric volume, free acidity, total acidity as compared to the control group. The intensity of heamorrhage and lesions was significantly reduced upon pretreatment with the extract, revealing the protective effect of ethanol extract.
Keywords: Ipomoea reniformis, antiulcer, pyloric ligation and ethanol
