Chaitali Kolekar, Shriniwas P. Patil*, Subhash T. Kumbhar
SCES’s Indira College of Pharmacy, Tathawade, Pune (Maharashtra), India
*Address for Corresponding Author:
Mr. Shriniwas P. Patil
SCES’s Indira College of Pharmacy, Tathawade, Pune (Maharashtra), India
Abstract
Objective: Flavonoids are type of polyphenolics biosynthesized by plants, several times proved to have anti-inflammatory activity. Several attempts have been made to synthesize flavonoids with desired substitution at desired place in order to get therapeutically better entity with reduced side effects. In present research attempt, substituted 3- benzoyl flavone 3 was synthesized via modified Baker-Venkatraman reaction. Material and methods: the chemical structure of the newly synthesized compound was confirmed by 1H NMR, MS, IR spectral data and evaluated for its anti-inflammatory activity following Human RBC membrane stabilization model. Results and conclusion: On screening, it was found that, compound 3 has significant and dose-dependent HRBC membrane stabilization activity as compared to standard, diclofenac. Topological polar surface area (TPSA) of compound 3 indicated that it exerts the membrane stabilization potential after being entered into it.
Keywords: Substituted 3-benzoyl flavone, Baker-Venkatraman reaction; HRBC membrane stabilization activity, Three-dimensional study
