Rameshwar Dass1, D. C. Bhatt2, S. K. Singh2
1Guru Gobind Singh College of Pharmacy, Yamunanagar-135001, Haryana, India
2Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, India
*Corresponding author
Rameshwar Dass
Guru Gobind Singh College of Pharmacy,
City Center Road, Yamuna Nagar-135001, Haryana, India
Phone No. 09896503552, Fax-01732-200381
Abstract
Objective: In the current research work, chitosan, bovine serum albumin and sodium alginate microspheres containing metoclopramide hydrochloride were prepared and evaluated for in-vitro and ex-vivo performance of metoclopramide hydrochloride. Materials and methods: Microspheres containing metoclopramide hydrochlorides were prepared by emulsification solvent evaporation method. The surface morphological characteristics of different microspheres were investigated using microscopy. The polymer ratio, stirring speed and the temperature affected the particle size, shape and surface morphology of the microspheres. The in-vitro drug release was carried out using USP paddle type dissolution rate test apparatus phosphate buffer (pH 7.4) dissolution medium at 272nm. Results and conclusion: The best entrapment was achieved in chitosan microspheres i.e. 91.95%. By, above results it was concluded that chitosan microspheres showed reproducible results and with good surface morphology. The above study results that metoclopramide hydrochloride microspheres appropriate system for nasal delivery.
Keywords: Metoclopramide hydrochloride, chitosan, bovine serum albumin, sodium alginate, nasal delivery
