Manjunatha P. Mudagal*, Suresh Janadri
Department of Pharmacology,
Acharya and B.M. Reddy College of Pharmacy, Soldevanhalli, Acharya Dr. SarvepalliRadhakrishna Road, Bengaluru-560090, Karnataka, India
*Address for Corresponding Author
Department of Pharmacology,
Acharya and B.M. Reddy College of Pharmacy,
Soldevanhalli, Acharya Dr. SarvepalliRadhakrishna Road,
Bengaluru-560090, Karnataka, India
Abstract
Objective: Polymer-drug conjugates have gained much attention largely to circumvent lower drug solubility and to enhance drug stability. Curcumin is widely known for its medicinal properties including its anticancer efficacy. One of the serious drawbacks of curcumin is its poor water solubility which leads to reduced bioavailability. Materials and methods: Synthesized hyaluronic acid–curcumin (HA–Cur) conjugate. The drug conjugate was characterized using FT-IR technique. The conjugates, interestingly found to assembles as micelles in aqueous phase. The formationof micelles seems to improve the stability of the drug in physiological pH. We also assessed cytotoxicity of the conjugate usingMCF-7, HBL 100 and Hela cell line and quantified by MTT assay. Results: The results showed Conjugate (HA–Cur) produced extremely significant reduction in percentage cell viability in dose dependent inhibitory effect on growth of cell lines. Conclusion: Conjugated curcumin also showed cytotoxicity reflecting its potential in targeted drug delivery applications.
Keywords: Curcumin, conjugate, cytotoxicity, anticancer
