Baskaran Krishnan1, Kodukkur Viswanathan Pugalendi2, Ramalingam Saravanan2*
1Assistant Professor, Department of Biochemistry, Sree Narayana Guru College, Coimbatore, Tamilnadu, India
2Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India
*Address for Corresponding Author:
Dr. R. Saravanan,
Assistant Professor
Department of Biochemistry and Biotechnology,
Annamalai University, Annamalainagar–608 002, Tamilnadu, India
Abstract
Objectives: Oxidative stress (OS) has been suggested as a contributory factor in the development and complication of diabetes. The aim of the present study was to evaluate the effects of Chrysoeriol (CS) on altered lipid peroxidation products, enzymatic and nonenzymatic antioxidants and hepatic marker enzymes in Streptozotocin (STZ) -induced diabetic rats. Material and Methods: Experimental diabetes was induced by a single intraperitoneal (i.p) injection of STZ (40 mg/kg body weight). Results: Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances (TABRS), lipid hydroperoxides (LOOH), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and decreased levels of plasma insulin and body weight. The activities of enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione (GSH) were decreased in diabetic rats. Oral treatment with CS (20 mg/kg/BW) for a period of 45 days showed significant ameliorative effects on all the biochemical parameters studied. Conclusions: Biochemical findings were supported by histological studies. These results indicated that CS has potential ameliorative effects in addition to its antidiabetic effect in type 2 diabetic rats.
Keywords: Oxidative stress, Chrysoeriol, intraperitoneal, antioxidants
