Research Articles

2018  |  Vol: 4(5)  |  Issue: 5 (September- October)  |  https://doi.org/10.31024/ajpp.2018.4.5.16

Neuroprotective effect of Sesbania sesban on Scopolamine induced amnesia in wistar rats: Behavioral and biochemical study

Mayur Kale^1*, Swati Kolhe², Sachin Tembhurne³

Department of Pharmacology, AISSMS College of Pharmacy, Kennedy road, Near R.T.O., Pune-411001, Maharashtra, India

*Address for Corresponding Author

Mr. Mayur Kale,

AISSMS College of Pharmacy, Kennedy road, Pune, 411-001, India.

Abstract

Objective: The present work was carried out to evaluate the effects of hydroalcoholic extract of Sesbania sesban (HAESS) on cognitive impaired rats. Materials and methods: In wistar rat’s amnesia was induced by subcutaneous administration of scopolamine butyl bromide (1mg/kg). Nootropic activity evaluated in terms of Spatial memory using T maze spontaneous alternation task. Results and conclusion: HAESS (400mg/kg) have shown significant level improvement in scopolamine-induced deficit with respect to recognition in spatial memory. The observed results suggest that hydroalcoholic extract of aerial parts of Sesbania sesban improves cognitive performance with respect to spatial memory processes.

Keywords: Acetylcholinesterase, antioxidant, amnesia, T-maze, Scopolamine