Review Articles

2020  |  Vol: 6(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2020.6.4.5

Promising actions of certain medicinal and dietary plants for the management of hyperuricemia as a natural remedy: A review

Ananya Das^1*, Prema Modak¹, Arghya Prosun Sarkar², Satyajit Halder¹, Bidduth Kumar Sarkar³, Anita Rani Chowdhury⁴, Sukalyan Kumar Kundu¹

¹Department of Pharmacy, Jahangirnagar University, Savar, Dhaka- 1342, Bangladesh

²Department of Pharmacy, Islamic University, Kushtia, Bangladesh

³Department of Pharmacy, Ranada Prasad Shaha University, Narayanganj, Bangladesh

⁴Department of Pharmacy, Jagannath University, Dhaka, Bangladesh

*Address for Corresponding Author

Ananya Das

Department of Pharmacy

Jahangirnagar University, Savar, Dhaka- 1342, Bangladesh

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Abstract

Hyperuricemia ensues due to the reabsorption and diminished evacuation of uric acid which is accountable for the advancement of gout and radically concomitant with the progress of numerous long-lasting ailments for instance malignant tumor, cardiovascular ailments, and kidney failure. Underlying factors such as excessive intake of purine containing supplements, obesity, age, sex, sugar, and alcohol intake may condense the formation of uric acid and exaggerate the injurious effects of uric acid. Novel inventive pharmaceutical and curative mediations are being used for the tackling of hyperuricemia but the problem arises when patients complain about adverse reactions with serious complications that may increase the rate of developing new diseases. Medicinal and dietary plants with bioactive phytochemicals like polyphenols, flavonoids are more feasible due to less toxicity, more economical for developing countries, formulation advantages for primary healthcare, better appropriateness with human physiological conditions. To facilitate the design of plant-based alternative therapy it is a prerequisite to connecting herbal medicine with novel prescription and additional precise explorations have to be ensured for the authentication of the effectiveness and safety of herbal formulations. The existing assessment outlines production, metabolism, and excretion of uric acid, hazard influences (overabundance and low excretion of uric acid), conventional pharmacotherapy for hyperuricemia and its related complications, the use of plants, its origin; parts to be used, mechanism of actions to preclude hyperuricemia are highlighted based on of previously issued literature.

Keywords: Uric acid, hyperuricemia, dietary plants, bioactive phytochemicals, xanthine oxidase inhibitory activity