Sonia Verma, Chandra Prakash Jain, Lalit Singh Chauhan, Ajay Kumar Shukla
Department of Pharmaceutical Sciences,
Mohan Lal Sukhadia University, Udaipur, India
Address for Corresponding Author
Mr. Ajay Shukla
Department of Pharmaceutical Sciences,
Mohan Lal Sukhadia University, Udaipur, India
Abstract
Objective: Neuropathic pain condition is generally definite as a chronic pain state resulting from peripheral or central nerve injury also due to acute events (e.g., amputation, spinal cord injury) or systemic disease (e.g., diabetes, viral infection and cancer) and categorized by pathological symptoms, such as hyperalgesia and allodynia to mechanical and thermal (heat or cold) stimuli, as well as spontaneous pain. Method: Bibliographic information were collected and analysed from text books and peer reviewed journals, consulting worldwide accepted scientific databases from the libraries and internet sources. Peripheral processes in neuropathic pain engage production of intermediaries (cytokines, protons, nervegrowth factor), alterations of calcium channels, sodium channels, hyperpolarisation-activated nucleotide-gated ion channels, potassium channels, phenotypic switches and sprouting of nerves endings, and involvement of the sympathetic nervous system. Results and conclusion: Neuropathic pain has been treated by the two major classes of drug like analgesics, opioids and nonsteroidal anti-inflammatory drugs. Moreover, both opioids and nonsteroidal anti-inflammatory drugs generate difficult side effects, particularly with prolonged use as may be necessary in the treatment of chronic pain, which noticeably limit the clinical utility of these two classes of longer term use, but also produce side effects, ranging from dry mouth to the potential for cardio toxicity, which can limit their clinical utility. This review covered all herbal drugs which have been reported for the treatment of neuropathic pain.
Keyword: Neuropathic pain, herbal medicine, Neuroprotective, Nonsteroidal anti-inflammatory drugs
