Research Articles

2018  |  Vol: 4(5)  |  Issue: 5 (September- October)  |  https://doi.org/10.31024/ajpp.2018.4.5.22

Hypolipidaemic effect of ethanolic extract of Ipomoea aquatic, Trigonella foenum graecum and Bryophyllum pinnatum in experimental animals

Urmi Choudhury¹, Ratan J. Lihite², Binita Singha¹, Mangala Lahkar^1*

¹Dept. of Pharmacology, Gauhati Medical College & Hospital (GMCH), Guwahati-781032, Assam, India

²Dept. of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam, India

*Address for Corresponding Author

Dr. Mangala Lahkar

Professor and Ex-HOD,

Gauhati Medical College & Hospital (GMCH), Guwahati-781032, Assam, India

Abstract

Objective: The aim of present study was to evaluate the hypolipidemic effect of ethanolic extract of Ipomoea aquatic, Trigonella foenum graecum and Bryophyllum pinnatum in experimental animals. Materials and methods: Hyperlipidemia was induced by daily administration of 1 ml/100 g body weight of a cocktail containing high fat diet. The serum lipid levels were estimated on day 0, 15 and 29 using Rayoto semiauto chemistry analyzer (RT 9600) and assay kits. Results and conclusion: Hyperlipidemia is a condition of excess fatty substances called lipids, largely cholesterol and triglycerides, in the blood. Ethanolic extract of Ipomoea aquatic, Trigonella foenum graecum and Bryophyllum pinnatum possessed significant hypolipidemic effect and reduced atherogenic changes in cholesterol rich cocktail diet induced hyperlipidemia in rats. The effects were however lower than the effects shown by the standard drug atorvastatin treated group which has showed the most significant effects compared to all doses of the test drugs.   

Keywords: Ipomoea aquatic, Trigonella foenum graecum, Bryophyllum pinnatum, hyperlipidemia