Research Articles

2015  |  Vol: 1(2)  |  Issue: 2(Nov-Dec)

Ameliorative effect of Alpinia galanga rhizomes on Freund's complete adjuvant induced arthritis in mice

Sharad Bhandarkar¹, Alok Pal Jain^2*

¹Institute of Pharmacy Abdul Majeed Central Education Society, Nagpur, Maharashtra, India

²RKDF College of Pharmecy, SRK University, Hoshangabad Road, Misrod, Bhopal - 462026 (MP) M.P., India

Corresponding author

Dr. Alok Pal Jain

RKDFCollege of Pharmecy

SRKUniversity, Hoshangabad Road,

Misrod, Bhopal - 462026 (MP)

Abstract

Arthritis is a inflammatory autoimmune disorder resulting in joint that is marked by swelling, pain, functional destruction and muscle wasting. The objective of present study was to evaluate rhizomes of Alpinia galanga for Freund’s complete adjuvant induced arthritis in mice model. Materials and methods: Ethanolic extract with the dose of 100 and 200mg/kg was tested for antiarthritic activity using Freund’s complete adjuvant model in mice. Activity was measured by paw edema measurement and observation of haematological parameters i.e. Leukocyte Count, Packed Cell Volume (PCV), and Rheumatoid Factor (RF), in the serum 28^th days after CFA administration. Results: Antiarthritic potential of ethanolic extract found on dose dependent manner and 200mg/kg dose of extract was significantly observed. Results also supported by improved various inflammatory markers in plasma. Conclusion:  Study can be concluded that the effect of ethanolic extract may be due to presence of flavonoids in the extract.

Keywords: Alpinia galangal, Arthritis, Freund’s complete adjuvant