Rizaldy Taslim Pinzon1*, Florentina Kassandra2, Rosa De Lima Renita Sanyasi3
1Duta Wacana Christian University School of Medicine, Dr. Wahidin Sudirohusodo 5-25, Special Region of Yogyakarta, Indonesia, 55224
2Faculty of Pharmacy Sanata Dharma University, Affandi Tromol Pos 29, Special Region of Yogyakarta, Indonesia, 55002
3Internship Doctor at dr. Efram Harsana Air Force Hospital, Raya Solo, Magetan, East Java, Indonesia, 63392
*Corresponding author:
Rizaldy Taslim Pinzon, MD, PhD,
Duta Wacana Christian University School of Medicine
Dr. Wahidin Sudirohusodo 5-25, Special Region of Yogyakarta, Indonesia, 55224
Abstract
Background: Parkinson’s disease (PD) is a neurodegenerative in central nervous system, characterized by tremor, rigidity, akynesia, and postural instability. Previous studies showed hypertension and certain drug, such as amlodipin, increasing PD risk. But the results from previous studies are conflicting. Objective: This study aimed to measure the risk of PD related to hypertension and use of amlodipin. Method: This study is a case control study. The case group were 59 PD patients and the control group were 118 patients without PD at Bethesda Hospital, matched by age and gender. Each subject on both group were agree to be interviewed and signed the informed consent form. Supplementary data obtained from medical record. The data were analyzed using chi square test and fisher test, continued by multivariate analysis using logistic regression analysis. Results: The subjects were dominated by male (50.8%) and >60 years old (87.7%). The proportion of hypertension in PD group is 35 subjects. The proportion of hypertension in control group is 84 subjects. This study showed that hypertension did not increase the risk of PD (p: 0.113). The most common prescribed antihypertensive drug was amlodipine 5 mg. Most of subjects using amlodipin alone rather than combination (66.2% vs 2.6%) and have been using amlodipin for ≥2.5 years. Bivariate analysis showed that among patients with hypertension, the use of amlodipin does not increase the risk of PD (p: 0.733). Conclusion: The results of this study showed that hypertension and the using of amlodipin do not increase the risk of PD.
Keyword: Parkinson, hypertension, amlodipin, anti hypertensive drug
