Sharad Bhandarkar, Ajay Shukla, Alok Pal Jain*
Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology
Jabalpur, M.P.
*Correspondence address
Dr. Alok Pal Jain
Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology
Jabalpur, M.P.
Email: dralokpaljain@gmail.com
Phone No. +919424445104
Abstract
Objective: In the present study we describe in-vitro efficacy of Cocos nucifera L. (family Arecaceae) husk fiber extract ointment for growth inhibition of four microbes (Candida albicans, Aspergillus fumigatus, Staphylococcus aureus and Trichosporon asahii) that may cause severe infection in eczema patient. Materials and methods: The stability parameters of extract ointment such as physical stability, spreadibility, centrifugation etc. would be performed and found applicable results. The therapeutic effect was compared with marketed product Tacrolimus 0.1%w/w ointment. Results: The shells of Cocos nucifera L. has rich in polyphenolic compounds and has been reported for arthritis, diarrhoea, antibacterial, antiviral and also has inhibitory lymphocyte production. Catechins are flavonoids that were present in Cocos nucifera L shells, already have antioxidant, powerful cellular growth inhibitor and anti-inflammatory activity which might be correlated with this study. Conclusions: The aqueous extract ointment of Cocos nucifera L was found effective and require further in-vivo study for eczema as well as isolation of responsible active constituents for this activity.
Key words: Cocos nucifera, eczema, Tacrolimus, polyphenols, ointment
