Khushboo Lowanshi, Rajesh Singh Pawar*
Truba Institute of Pharmacy, Karond, Bypass Road, Bhopal, 462038, Madhya Pradesh, India
*Address for Corresponding Author
Dr. Rajesh Singh Pawar
Professor and Principal
Truba Institute of Pharmacy, Karond, Bypass Road, Bhopal, 462038, Madhya Pradesh, India
Abstract
Background: Topical delivery of drugs can be achieved by incorporating drug into the gel matrix for effective delivery of drugs, thus avoiding first pass metabolism and for increased local action in pain management and skin diseases. Transdermal delivery of Ketorolac has drawn much attention for the advantages of avoiding first-pass metabolism, reduced gastrointestinal side effects as bleeding, peptic ulcer, perforation, but the successful translation of reported transdermal drug delivery systems (TDDSs) is still limited by poor skin permeability and uncontrollable drug release. Objective: Present study was aimed to prepare hydrogel of ketorolac and overcome all the problems cause by oral administration of that drug. Material and methods: Herein, we designed hydrogel of ketorolac which are more stable in accelerated stability conditions at 40ºC ± 2ºC/ 75% RH ± 5%. Results and conclusion: Drug release profile study revealed that hydrogel preparation could be used for local or site-specific delivery of drug. Ketorolac Hydrogel could be better formulated and used commercially with various advantages over other dosage form. It could be used topically for site-specific drug delivery for any conditions of pruritus, insect bite induced urticarial, allergic conditions. Ketorolac hydrogel preparation was found to be acceptable, elegant and more patient compliance than other dosage form of this drug.
Keywords: Ketorolac, hydrogel, drug delivery, carbopol, dermatitis
