Dinesh Dangar1, Nilesh Patel2*
1Research scholar, Ganpat University, Ganpat vidyanagar, Mehsana, Gujarat, India
2Associate Professor & HOD, SKPCPER, Ganpat University, Ganpat vidyanagar, Mehsana, Gujarat, India
*Address for Corresponding author:
Dr. Nilesh J. Patel
Associate Professor & HOD,
Department of Pharmacology,
S. K. Patel college of Pharmaceutical Education and Research, Ganpat University, Ganpat vidyanagar-384012 Kherva, Mehsana, Gujarat, India
Abstract
Objective: Neuracanthus sphaerostachyus has been used traditionally to cure skin diseases, cough, and asthma in western ghat. Extensive review of literature and evidences indicating the utility of this plant in the treatment of asthma prompted us to investigate the anti-asthmatic activity of the plant in different experimental screening methods. Materials and Methods: In vitro & in-vivo anti-asthmatic activity of the methanolic and aqueous extract of Neuracanthus sphaerostachyus leaves was investigated using various experimental models. In-vivo studies like compound 48/80 induced systemic anaphylaxis and In-vitro studies like compound 48/80 induced mast cell degranulation, Milk induced leucocytosis & eosinophilia was evaluated at 125, 250, and 500 mg/kg, orally doses. Results: Methanolic and aqueous extract of the drug showed a significant bronchodilation, anti-histaminic, mast cell stabilizing, and anti-cholinergic activity in their respective evaluation parameters dose-dependently. Ketotifen fumarate (10 μg/ml), Dexamethasone (50 mg/kg) and Disodium chromoglycate (10 mg/kg) were used as a standard control. Conclusion: The present study concluded that methanolic and aqueous extract of Neuracanthus sphaerostachyus has significant anti-asthmatic potential benefit.
Keywords: Neuracanthus sphaerostachyus, compound 48/80, mast cell degranulation, leukocytosis, eosinophilia
