Research Articles

2017  |  Vol: 3(5)  |  Issue: 5(September-October)

Spectrophotometric methods for determination of ticagrelor in dosage forms

Effat Souri^1*, Kawthar Majid Hamid¹, Maliheh Barazandeh Tehrani¹, Hassan Jalalizadeh²

¹Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran (14155-6451), Iran

²Department of Research and Development, Alborz-Zagros Pharmaceutical Company, Tehran, Iran

^*Address for Corresponding Author

Dr. Effat Souri

Department of Medicinal Chemistry,

Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran (14155-6451), Iran

Phone: (98 21) 66959065; Fax    : (98 21) 66461178 

Abstract

Objective: The aim of this study was to develop simple and rapid spectrophotometric method for determination of ticagrelor in dosage forms. Materials and methods: Two rapid and accurate spectrophotometric methods were described for the determination of ticagrelor in pharmaceutical dosage forms. In the first method direct spectrophotometry was used for the quantification of ticagrelor at 255 nm. The second method was based on the ion-pair complex formation of ticagrelor and bromocresol green extractable in chloroform. After optimization of the reaction, the resulting complex was measured at 416 nm. Results and conclusion: Linear calibration curves were obtained at the range of 0.5-25 µg mL^-1 and 5-1000 µg mL^-1 for the direct and ion-pair complex formation method, respectively. Validation parameters were satisfactory for both methods. The proposed methods were applied for the determination of ticagrelor in tablets without any interference from excipients.

Keywords: Ticagrelor, Bromocresol green, Ion-pair complex formation, Spectrophotometry