Research Articles

2017  |  Vol: 3(5)  |  Issue: 5(September-October)

Preliminary neuroprotective activity of aerial parts of Enicostemma littorale Blume extract in albino rats

Vinuth Chikkamath, Shanmukha I.*

PG Dept of Pharmacology S.C.S College of Pharmacy, Harapanahalli, Davanagere 583131

Karnataka, India.

*Corresponding author:

Shanmukha I.

PG Dept of Pharmacology, S.C.S College of Pharmacy, Harapanahalli, Davanagere 583131

Karnataka, India.

Abstract

Objective: The main aim of this research paper is to evaluate the neuroprotective activity of Enicostemma littorale Blume of 70% ethanolic extract against Monosodium Glutamate (MSG) and Aluminium fluoride (AlF₃) treated albino rats. Materials and methods: The Enicostemma Littorale, extracted from Soxhlet apparatus unit, by using 70% ethanol and evaluated, in the course of free radical generation and excitotoxicity in Monosodium Glutamate (MSG) and Aluminium fluoride (AlF₃) treated albino rats. Results and conclusion: The extract showed significant improvement in body weight, total protein, Catalase, super oxide dismutase, and lipid peroxide levels. The general behavior, locomotor activity, and region of the hippocampus were significantly protected by organ protective properties of ethanolic extract of Enicostemma Littorale Blume attribute to its antioxidant and behavioral properties.

Keywords: Neuroprotective, Enicostemma littorale Blume, Monosodium glutamate, Aluminium fluoride.