Rishabh Pandey*, Prashant Singh, Rajeev Shukla
Sheat College of Pharmacy, Gahani, Varanasi, UP- 221001 India
*Address for Corresponding author:
Rishabh Pandey
Sheat College of Pharmacy, Gahani, Varanasi, UP- 221001 India
Abstract
Objective: The present pharmacological investigation was undertaken to study the effect of roots, fruits and flower of nirgundi plant on antipyretic and astringent activity by albino rat. Materials and methods: The pharmacognostic study of crude plant materials used and were performed and determined extractive values, ash values, loss on drying. The ethanolic extracts was prepared and phytochemical tests performed. The antipyretic and astringent activity of roots, fruits and flower of nirgundi was assessed by using in-vivo albino rat model. Results: The extractive values of Vitex negundo different parts used and were determined and found to be roots 12.40, fruits 15.80, and 10.71%. Phytochemical tests were performed and found to be ash values of roots3.27, fruits4.80 and 1.16% respectively. Extractive value ethanol soluble of extract values of Vitex negundo was discovered to be % that are Root extract values of Vitex negundo was 13.01, 14.30 and flower 10.06. Loss on Drying values of Vitex negundo was discovered to be % that are Root extract values of Vitex negundo was 2.01, 4.35 and flower 1.60. Phytochemical Screening tests were performed by using different parts of Vitex negundo ethanolic extract such roots, fruits and flowers and was found to be roots of plants had good phytocompounds. Astringent Property for different parts of Vitex negundo extracts (VNEE) was found that, VNEE contains carbohydrates, alkaloids and flavonoids. On the other hand, it has astringent and antipyretic properties. Conclusion: The evaluation of results confirmed that potential bioactive molecules of plant materials responsible for the antipyretic and astringent activity. The results suggest that plant extract can be further developed as nutritional supplements, preventive medicines, and topical products for cosmetic purposes.
Keywords: Vitex negundo, pharmacognostic study, Phytochemical tests, antipyretic and astringent activity
