Geetanjali Purohit*, Bhavana Srivastava, Reena Bhardwaj, Sanjay Gaur
Department of Pharmacology, Govt. Medical College Haldwani.
Uttarakhand, India.
*Corresponding Author
Dr. Geetanjali Purohit
Department of Pharamacology
Govt. Medical College Haldwani
Uttarakhand- 263139 India.
Abstract
Objective: Toxic epidermal Necrolysis (TEN) and Steven Johnson syndrome (SJS) are two forms of a life threatening skin condition in which death of keratinocytes leads to separation of dermis from epidermis. Material and methods: The patient presents with fever, blister formation and denudation of skin involving whole body including the mucous membrane leading to severe dehydration and in extreme cases multiorgan failure with superadded infection leading to death. The most common cause are certain medications like antibiotics (sulphonamides, cephalosporin) anticonvulsants (carbamazepine, phenytoin), NSAIDs, antiviral, allopurinol etc. Presenting a case of an eight year old female patient who was suffering from Neurocysticercosis and was prescribed Tablet Carbamazepine 200mg twice daily, patient landed into emergency department with denudation of skin that involved more than 30% of body surface area, with fever and conjunctivitis. On examination blood pressure was low, with tachycardia and low urine output. Patient was managed in pediatric intensive care unit. WHO Causality assessment: probable: dechallenge done. Results and conclusion: Carbamazepine is a widely prescribed drug for Seizure and Trigeminal Neuralgias, physician should be aware with its adverse and life threatening side effects and drug should be prescribed judicially. The patient and care takers should also be encouraged to immediately report any abnormal manifestation following use of Carbamazepine to prevent potential life threatening condition.
Key words: Toxic Epidermal Necrolysis (TEN), Carbamazepine, WHO causality assessment
