Research Articles

2019  |  Vol: 5(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2019.5.1.11

Evaluation of Gymnospora montana (Celastraceae) fruit extract for anti-ulcer activity in rats

Kiran B. Kotade^*1, Shivanand N. Hiremath²

¹Shri J.J.T. University, Jhunjhunu, Rajasthan, India -333001

²P.R.E.S.’s, Pravara College of D Pharmacy, Loni, Ahmednagar, Maharashtra, India-413736

*Address for Corresponding Author

Kiran B. Kotade

Shri J.J.T. University, Jhunjhunu, Rajasthan, India -333001

Abstract

Objective: The objective of present study is to systematically investigate and confirm the folklore use of Gymnospora Montana fruits in different models of ulcer. Materials & methods:  The ethanolic extract of Gymnospora montana fruit were selected and equipped in doses of 100 and 500 mg/kg. The antiulcer activity of Gymnospora montana was evaluated by aspirin induced ulcers, pyloric ligation models and Cysteamine induced ulcers. Results: It was revealed that ethanolic extract had marked antiulcer activity in all these models at a dose of 500 mg/kg. In addition, it was also found to increase the mucin content of the gastric mucosa. The observed results were attributed to the rich content of flavonoids in the ethanolic extract. Conclusion: The present study affords a significant contribution in confirmation of the forklore effects of a traditional remedy.

Keywords: Gymnospora montana, Shay rats, duodenal ulcer, peptic ulcer, flavanoids