Ajay Kumar Shukla1*, Manish Kumar2, Maya Sharma3, Suresh Kumar Dev3, Rahul Maurya4
1Institute of Pharmacy, Dr Rammanohar Lohia Avadh University Ayodhya U.P, India
2Department of Pharmacy, Madhav University, Pindwara, Rajasthan, India
3Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India
4National Ayurveda Research Institute for Panchkarma, Cheruthuruthy, Kerala, India
*Address for Corresponding author
Dr. Ajay Kumar Shukla
Institute of Pharmacy, Dr. Rammanohar Lohia Avadh University Ayodhya U.P, India
Abstract
Usnic acid is a dibenzofuran derivative found naturally in P. reticulatum, a natural lichen. Natural lichen-derived usnic acid is a powerful antibacterial, anti-inflammatory, and antioxidant substance. Due to its capacity to encourage tissue regeneration and lower infection rates, it has attracted considerable attention as a possible bioactive agent for wound healing treatment. Usnic acid has the ability to speed up wound healing, especially in burns, diabetic ulcers, and chronic wounds, according to several in vitro and in-vivo investigations. Usnic acid is a topical wound therapy ingredient that can also be used as a wound dressing. However, more research is required to determine its effectiveness and safety in humans as well as the best formulation for uses in wound healing. Usnic acid is typically regarded as harmless when used topically, but when taken orally, some people may have liver damage. It is a promising bioactive agent for the treatment of wounds that has a lot of potential for use in clinical settings in the future. This review discussed the mechanism of usnic acid, formulations and potential future benefits of usnic acid for the treatment of wounds.
Keywords: Usnic acid, wound healing, antibacterial, anti-inflammatory, antioxidant, lichens
