Etou Ossibi A.W.1, 2, 3, Mouanda Ngouadi V. M.2, Wossolo Lingomo B. S.1, 2, 3, Mondzomba Limougna H. M.2, Et Abena A. A.1
1Biochemestry and Pharmacology, laboratory, Faculty of Health Sciences, Marien NGOUABI University, B.P. 69, Brazzaville, Congo
2Laboratory of Pharmacodynamics and Experimental Physiopathology, Faculty of Science and Technology, Marien NGOUABI University, B.P. 69, Brazzaville, Congo
3Biologiy Center, Faculty of Applied Sciences, Denis SASSOU-N'GUESSO University, Kintélé Congo
*Address for Corresponding author
Etou Ossibi A. W.
Biochemestry and Pharmacology, laboratory, Faculty of Health Sciences, Marien NGOUABI University, B.P. 69, Brazzaville, Congo
Abstract
Hypercholesterolemia is an excess of cholesterol in the blood, responsible for around 4,4 million deaths (7,9%) worldwide. It is a risk factor for cardiovascular disease, which accounts for 17,7 million deaths worldwide, representing a global mortality rate of 31 %. The aim of the present study was to evaluate the anti-hypercholesterolemic effect of aqueous extract of Hura crepitans L. (Euphorbiaceae) leaves in Wistar rats. The aqueous extract of Hura crepitans L. leaves was prepared by decoction. The effect of this extract on hypercholesterolemia induced by 4 % cholesterol was evaluated according to the standard protocol. To this end, six (6) batches of five (5) rats each were formed and treated for eight (8) weeks by gavage with the different products. Results showed that the aqueous extract of Hura crepitans L. significantly reduced ALAT, ASAT, creatinine, total cholesterol, LDL-cholesterol, triglycerides and the atherogenicity index, and increased HDL-cholesterol levels, compared to rats in the induction batch given 4% cholesterol alone. Chemical screening revealed the presence of metabolites such as flavonoids, alkaloids, tannins, anthraquinones, terpenoids, oses and holosides. This would justify the effects observed and its use in traditional medicine.
Keywords: Anti-hypercholesterolemic, cholesterol, Hura crepitans L.
