Prashant Soni, Alok Pal Jain*
Department of Pharmacology,
RKDF College of Pharmacy, Sarvepalli Radha Krishnan University, Bhopal (M.P.) India
*Address for Corresponding Author
Dr. Alok Pal Jain
Department of Pharmacology,
RKDF College of Pharmacy, Sarvepalli Radha Krishnan University, Bhopal (M.P.) India
Abstract
Objective: The aim of present study was to investigate polyherbal tablet containing methanol extracts of Carissa carandus, Ocimum sanctum, Moringa oleifrea, Manilkara zapota for screening of antidiabetic effects. Material and methods: The dried extracts of all four plants were mixed with different excipient using wet granulation method to prepare tablets using compressing machine. Prepared herbal formulation was tested for in vivo studies for antidiabetic activity by using Alloxan induced diabetes in rats. Effect of formulation was assessed by measurement of biochemical parameters and also estimation of antioxidant level. Results: Preformulation study of the granules showed that all the evaluated parameters were within the acceptable limit. Prepared polyherbal tablet was tested for antidabetic effect in alloxan induced diabetic animals showed significant reduction in body weight, blood glucose level, and lipid profile when compared to the control animals. The serum total cholesterol, and Triglyceride level were significantly (P<0.01) decreases and restore near to the normal level. Polyherbal formulation treated animals reversed the effect of Alloxan tissue antioxidant level. This may be due to the antioxidant mechanism of the individual herbs present in the polyherbal formulation. Conclusion Results of the present study was confirmed that prepared formulation was safe, and effective for antidiabetic activity. It was confirmed that prepared formulation was able to restore lipid profile, blood glucose level and antioxidants level to the nearly of normal. These positive effects may attribute to the presence of various flavonoid constituents present in methanol extracts of all plants. Additionally this formulation also showed antioxidant effect that may another possible mechanism for antidiabetic effect of formulation.
Keywords: Antioxidant, Carissa carandus, Ocimum sanctum, Moringa oleifrea, Manilkara zapota, ployherbal tablets, antidiabetic, Alloxan
