P. V. Sandhya1*, K. V. Satheesh Kumar2
1Department of Chemistry, Maharaja’s college, Ernakulam, Kerala, India, 682011
2Department of Chemistry, Government College, Kasaragod, Vidyanagar, 671123
*Address for Corresponding author:
Dr. Sandhya P. V.,
Associate professor in Chemistry, Maharaja’s College, Ernakulam, Kerala, India, 671123
Abstract
Objective: Pyrazoles and its derivatives have been explored in past and are still in practice for a variety of biological applications which make this scaffold as an interesting moiety for scientists especially in synthesis and designing new broad-spectrum pharmacophore. The objective of present study was to introduce a simple and efficient method to synthesis the compounds containing both substituted imino phenyl and pyrazole ring and investigate their biological activities both experimentally and theoretically. Materials and methods: The five membered N containing heterocyclic compounds have depicted various admirable biological properties in form of antioxidant, analgesic, antibacterial, antifungal activities. Clubbing imino or azo moiety to this compound has given a positive impact on its biological properties. Here we focused to synthesis pyrazole terminated imino phenyl derivatives and all the compounds were characterized by different spectroscopic techniques. The biological activities of the synthesized compounds were screened. The computational studies such as molecular docking with protein and DNA were also carried out. Results: All the synthesized compounds displayed moderate to good biological activities both experimentally and theoretically. Conclusion: From our compounds, pyrazole derivatives with electron withdrawing group at the 4th position of imino phenyl ring were showing more biological activities and molecular docking studies supported this finding.
Keywords: Vilsmeir -Haack reaction, pyrazole derivatives, antibacterial, antifungal, alamar blue assay, molecular docking, DNA binding
