Research Articles

2021  |  Vol: 7(5)  |  Issue: 5(September- October)  |  https://doi.org/10.31024/ajpp.2021.7.5.1

Peripheral analgesic activity of Moringa oleifera seeds - An experimental study

Abdul Haseeb M.^1*, Mohammed Ziauddin Sarkhil¹, Mohammed Fayazuddin², Farida Ahmad³

¹Department of Pharmacology, Kannur Medical College, Kannur - 670612 Kerala, India

²Department of Pharmacology, Raichur Institute of Medical Sciences, Raichur, Karnataka 584102 India

³Department of Pharmacology, Jawaharlal Nehru Medical College, AMU, Aligarh (Utter Pradesh) India

*Address for corresponding author

Abdul Haseeb M.

Department of Pharmacology, Kannur Medical College, Kannur - 670612 Kerala, India

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Abstract

Moringa oleifera Lam. commonly known as the drumstick tree, is widely used in Indian cuisine with a number of medicinal properties. Objective: The objective of this study was to evaluate the peripheral analgesic activity of Moringa oleifera seeds. Material and methods: The Peripheral analgesic activity was studied using Acetic acid induced writhing method in Swiss Albino mice of either sex weighing 20-40g at doses of EEMO 50 mg/kg, 100mg/kg, 200mg/kg and AEMO 250 mg/kg, 500mg/kg, 750 mg/kg. Statistical significance was calculated using One-way analysis of variance (ANOVA) followed by post hoc dunnett's test. Results: EEMO at all three doses 50 mg/kg, 100 mg/kg and 200 mg/kg exhibited peripheral analgesic activity by significantly decreasing the number of writhes, when compared to control group. AEMO at doses of 500 mg/kg and 750 mg/kg decreased the number of writhes significantly in comparison to control group. Conclusion: Moringa oleifera seeds exhibits Peripheral analgesic activity in Swiss Albino mice.

Keywords: Acetic acid induced writhing method, Moringa oleifera, peripheral analgesic activity