Research Article

2016  |  Vol: 2  |  Issue: 1 (Jan- Feb)

Gastroprotective activity of Martynia annua leaves on ethanol induced ulcer in rats

Suchit Jain¹, Sharad Bhandarkar²

¹School of Pharmaceutical Sciences, SOA University, Bhubaneswar, Odisha, India

²Institute of Pharmacy, Abdul Majeed Central Education Society, Nagpur, Maharashtra, India

*Corresponding address

Sharad Bhandarkar

Institute of Pharmacy, Abdul Majeed Central Education Society,

Nagpur, Maharashtra, India.

Abstract

Objective: Aim of present study was study gastroprotective activity of ethanol extract of Martynia annua leaves in rats. Materials and methods: Ethanol extract of M. annua was selected for study with 200 mg/kg and 300 mg/kg b.w. doses of extract on ethanol induced gastric ulcer. Effect of extract was observed by calculating ulcer index based on lesion index and pH. Results: Phytochemical screening confirmed the presence of flavonoids, glycosides and terpenoids in leaves of M. annua. Ethanol extract with both doses (200 mg/kg and 300 mg/kg) produced significant inhibition on the ulcer lesion index in rats. Effect of ethanol extract with 300 mg/kg dose significantly (p<0.05) change the gastric volume, ulcer index and pH. Conclusion: The results of the study indicated that significant inhibition of gastric lesions was found. The results of macroscopic observation also supported the gastroprotective effect and may be associated with its antioxidant property of flavonoids.

Keywords: Martynia annua, gastroprotective, flavonoids, antioxidant, omeprazole