Km. Saba Khan*, Shamim Ahmad, Anuj Kumar Sharma
Translam Institute of Pharmaceutical Education and Research, Meerut, Uttar Pradesh, India
*Address for corresponding author
Km. Saba Khan
Translam Institute of Pharmaceutical Education and Research, Meerut, Uttar Pradesh, India
Phone: +91 7417568853
Abstract
Objective: The present work was under taken to evaluate the anti-obesity effect of Rubia cordifolia leaves extract in Cafeteria diet induced obesity in rats. Materials and methods: Wistar rats weighing 150-180 g were randomly divided in to seven groups (n=6/group). Group І served as normal control & received vehicle; Group ІІ served as CD control & received vehicle; Group ІІІ received standard drug Orlistat (30 mg/kg); Groups ІV & V were administered with ethanolic extract of Rubia cordifolia leaves (250 & 500 mg/kg respectively) and Groups VІ & VІІ received aqueous extract of Rubia cordifolia leaves (250 & 500 mg/kg respectively). All treatments were given orally, started after 6 weeks feeding with CD (except normal control group) and continued for six weeks along with CD. Weight gain, feed intake, BMI, obesity index, lipid profile, blood glucose and body fat depots content were the parameters evaluated. Results: Ethanolic and aqueous extract of Rubia cordifolia leaves at 250 and 500 mg/kg showed reduction in weight gain, feed intake, BMI (Basal metaboilic rate, obesity index and significant decrease in serum glucose, triglyceride, and total cholesterol with increase in HDL (High density lipoprotein), level. Also these were significant decrease body fat depots when compared to CD control group. Conclusion: Present study revealed that aqueous and ethanolic extracts of Rubia cordifolia leaves extracts possess significant anti-obesity activity against Cafeteria diet induced obesity in rats and that could be due to presence of flavonoids, tannins, diosgenin and saponins. However, detailed phyto-pharmacological study of leaves extracts will be useful to pin point the activity.
Keywords: Rubia cordifolia, anti-obesity, Cafeteria, obesity index, lipid profile
