Hemalatha B.1 , Jeevika V. M.1 , Julega K. S.1 , Mohankumar M.2* , Venkateshan N.3
1Doctor of Pharmacy, Arulmigu Kalasalingam College of Pharmacy, Krishnan Koil, Tamil Nadu, India
2Assistant Professor, Department of Pharmacy Practice, Arulmigu Kalasalingam College of Pharmacy, Krishnan Koil, Tamil Nadu, India
3Professor, Department of Pharmaceutical Chemistry , Arulmigu Kalasalingam College of Pharmacy, Krishnan Koil, Tamil Nadu, India
*Address for Corresponding Author
Dr. Mohankumar M.
Assistant Professor,
Department of Pharmacy Practice, Arulmigu Kalasalingam College of Pharmacy, Krishnan Koil – 626 126, Tamil Nadu, India
Abstract
Background: Schizophrenia is a chronic heterogeneous syndrome of delusion, Hallucination, disorganized and bizarre thoughts, cognitive deficits and impaired psychosocial functioning Objective: The objective of the study is to evaluate the efficacy among antipsychotic drugs and assess the demographic details, clinical characteristics of schizophrenia. Materials and Methods: A prospective observational study was conducted in a tertiary care hospital, Virudhunagar. Results: A total of 50 patients were enrolled in the study. Out of 50, males were 28 (56%) and females were 22 (44%) Majority of the patients were in the age group of 28-38 years (50%) followed by 18-28 years (50%), 38-48 (6%) and 48-60 years (4%). In this study SES (socio economic scale) was classified according to modified kuppuswamy scale 2019 and the majority of patients were from Upper lower (32%) followed by Upper middle (28%), Lower middle (28%) and lower (12%). Most number of patients were admitted with complaints of both positive (hallucinations and delusions) and negative (flat effect and alogia) (60%) and followed by positive (16%), positive and cognitive (12%), positive, negative and cognitive (12%). Risperidone was most prescribed drug followed by combined drugs of THP and diazepam (66%) Risperidone reduce positive and negative symptoms compared to other Psychotic drugs. Olanzapine reduce the General Psychopathology symptoms compared to other psychotic drugs and shows statistically difference between the baseline and discharge time that was confirmed by using PANSS. Conclusion: Risperidone reduce both positive and negative symptoms compared to other antipsychotics and improves the patient’s quality of life.
Keywords: Schizophrenia, antipsychotic drugs, hallucination, risperidone, kuppuswamy scale
