Sanman Samova*, Hetal Doctor, Dimple Damore, Ramtej Verma
Department of Zoology, BMTC and Human Genetics, School of Sciences, Gujarat University, Ahmedabad, India
*Address for Correspondence:
Sanman Samova
Department of Zoology,
University School of Sciences, Gujarat University, Ahmedabad-380009, India
Abstract
Objective: Bisphenol A is an endocrine disrupting chemical, widely used as a material for the production of epoxy resins and polycarbonate plastics. Food is considered as the main source of exposure to BPA as it leaches out from the food containers as well as surface coatings into it. BPA is toxic to vital organs such as liver kidney and brain. Quercetin, the most abundant flavonoid in nature, is present in large amounts in vegetables, fruits and tea. The aim of the present study was to evaluate the toxic effects of BPA in prostate gland and seminal vesicle of mice and its possible amelioration by quercetin. Material and methods: Inbred Swiss strain male albino mice were orally administered with BPA (80, 120 and 240 mg/kg body weight/day) for 45 Days. Oral administration of BPA caused significant, dose-dependent reduction in absolute and relative weights of prostate gland and seminal vesicle. Results and conclusion: Biochemical analysis revealed that protein content reduced significantly, whereas acid phosphatase activity increased significantly in prostate gland and reduction in fructose content was observed in seminal vesicle. Oral administration of quercetin (30, 60 and 90 mg/kg body weight/day) alone with high dose of BPA (240 mg/kg body weight/day) for 45 days caused significant and dose-dependent amelioration in all parameters as compared to BPA along treated group. Histopathological alterations were also ameliorated by quercetin. BPA causes toxicity in prostate gland and seminal vesicle of mice and quercetin is potent enough to ameliorate BPA induced toxicity.
Keywords: Bisphenol A, male accessory glands, prostate gland, seminal vesicle, biochemical analysis, histopathology
