Vineeta Shyam1, Kapil Khatri1, Satish Shilpi1*
1*Pharmaceutical research laboratory, Department of Pharmaceutics,
Ravishankar College of Pharmacy, Bypass Road, Bhanpur Square, Bhopal (MP) India
*Corresponding Author
Dr. Satish Shilpi
Pharmaceutical Research Laboratory
Department of Pharmaceutics,
Ravishankar College of Pharmacy,
Bypass Road, Bhanpur Square, Bhopal (MP), India
Abstract
Objective: Salbutamol is a medication that opens up the medium and large airways in the lungs and it is used to treat asthma, exercise-induced bronchospasm, and chronic obstructive pulmonary disease (COPD). The objective of this dissertation work was to prepare salbutamol loaded microspheres using carbopol, Materials and methods: HPMC and sodium CMC for the purpose of effective management of asthma by delivering drug for long period of time in a controlled manner by making them mucoadhesive. Microspheres prepare by emulsification‐heat stabilizing method and characterize on the basis of size, shape and surface morphology, drug content and drug release. Results: Microspheres were spherical shape and smooth in surface confirmed by scanning electon microscopy (SEM). The average size was found to be 12.14±2.53 µm and drug content was 80.15±1.02%. An in-vitro drug release study was revealed that microsphere release 52.16±1.76% drug in 24 hr. Conclusion: It is concluded that prepared microspheres of salbutamol can be prepared by emulsification heat stabilizing method for high drug encapsulation and controlled drug release.
Keywords: Salbutamol, Microspheres, HPMC, Sodium CMC, Drug release
